منابع مشابه
21 years of biologically effective dose.
In 1989 the British Journal of Radiology published a review proposing the term biologically effective dose (BED), based on linear quadratic cell survival in radiobiology. It aimed to indicate quantitatively the biological effect of any radiotherapy treatment, taking account of changes in dose-per-fraction or dose rate, total dose and (the new factor) overall time. How has it done so far? Accept...
متن کاملBiologically effective dose in fractionated molecular radiotherapy--application to treatment of neuroblastoma with (131)I-mIBG.
In this work, the biologically effective dose (BED) is investigated for fractionated molecular radiotherapy (MRT). A formula for the Lea-Catcheside G-factor is derived which takes the possibility of combinations of sub-lethal damage due to radiation from different administrations of activity into account. In contrast to the previous formula, the new G-factor has an explicit dependence on the ti...
متن کاملComparison of breast sequential and simultaneous integrated boost using the biologically effective dose volume histogram (BEDVH)
PURPOSE A method is presented to radiobiologically compare sequential (SEQ) and simultaneously integrated boost (SIB) breast radiotherapy. METHODS The method is based on identically prescribed biologically effective dose (iso-BED) which was achieved by different prescribed doses due to different fractionation schemes. It is performed by converting the calculated three-dimensional dose distrib...
متن کاملApplications of the Biologically Effective Uniform Dose to Adaptive Tomotherapy and Four-dimensional Treatment Planning
The ultimate goal of radiation therapy is to efficiently deliver radiation in order to eradicate tumors, while adequately sparing nearby normal tissues. With the emergence of advanced technologies in radiation delivery, more and more conformal radiation delivery has been achieved in order to overcome challenges such as motion management between treatment fractions as well as during radiation de...
متن کاملA meta-analysis of the abscopal effect in preclinical models: Is the biologically effective dose a relevant physical trigger?
BACKGROUND Preclinical in vivo studies using small animals are considered crucial in translational cancer research and clinical implementation of novel treatments. This is of paramount relevance in radiobiology, especially for any technological developments permitted to deliver high doses in single or oligo-fractionated regimens, such as stereotactic ablative radiotherapy (SABR). In this contex...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The British Journal of Radiology
سال: 2010
ISSN: 0007-1285,1748-880X
DOI: 10.1259/bjr/31372149